CAB CALLOWAY SCHOOL of the ARTS

Paroxetine versus other anti-depressive agents for depression | Cochrane

I suffered from anxiety and depression which I learned it was inherited from my grandfather who killed himself by jumping off an an apartment building. When I grew up in the 50s doctors did not know much. They know so much more now so just ask for help like I did. Depression is the evil period! Paxil helped me treat my depression but as soon as I determined my symptoms of depression was due to ADHD I decided to get off of it.

It's been like living in the depths of a dark pit. Paxil helps you but destroys you. Please please please please please weigh your options. I can and can't suggest this medication or any antidepressant. I urge you to determine what is causing your depression and treat that underlying problem. It will save you from these types of medication that will develop a strong dependence and the minute you do not need them and decide to go off them, it's going to be an absolute WAR!

It is possible stay strong, stay positive. Always get second opinions never assume because you owe it to your life. Keep your head up follow your gut instincts and it will all work out for the best!

The drug made me feel severely disoriented and like I wasn't in control; it gave me severe anxiety and made my dark feelings worse. I ended up attempting suicide after taking it. I have since learned that there are thousands of people who had the same experience with this drug. I warn people against taking it, due to the side effects - it nearly cost me my life and was the source of pain and humiliation for many years. May help with depression, but it's a very hard drug to get off of.

Would very much like to post my full and very real experience. I just turned 60 and have been taking it since and it was miraculous. I never ever ever want to feel how I did previously. Paxil did help calm my anxiety but also made me veeeery lazy and letharged and didn't really help the depression totally.

So my overall quality of life didn't improve as much as I would have liked on this med. I feel like this might be a better med for just anxiety than depression for some people? But try something else first if you can.. I took it as a teen over 15 years ago. Worst thing I could have ever taken! The first time I took it I wanted to die. I was so sad. I didn't want to feel like that. When I do it's not the same and never has been since.

It makes me depressed just thinking about that. I was misdiagnosed with depression because I was a rebellious teen. Now I'm stuck with the side effects for life probably. I don't know if I'll ever be the same after this drug. Don't take it. Discussed meds I was on with a neurologist.

He found that Paxil was causing my symptoms. I changed meds and symptoms have disappeared. It worked for the depression, but it is not worth the side effects for me. This medication has helped me tremendously with my depression and OCD. I still have problems, but they are much less severe.

The only thing I really do not like about this medication is what it has done to my body. I am naturally thin but this medication has made me gain weight, about 10 pounds.

And the worse part is that I have bloating in my stomach area. This medication does also increase your appetite. I always feel everyone hates me. That I am useless. Paxil started off wonderful. Was on 20mg. I was on this high for weeks.

I was goofy, fun, talkative. A massive opposite to what I was before when I started paxil. It felt like I was in another body. Now and then I would go out with friends or have a date night with my husband and have a drink or two. As soon as I had that ONE drink since starting paxil There was some evidence that paroxetine is less well tolerated than agomelatine and St John's Wort, as more patients allocated to paroxetine experienced at least some side effects though this finding for St John's Wort was only based on one study.

In conclusion, some possibly meaningful differences between paroxetine and other antidepressants exist, but no definitive concluions can be drawn due to the limited number of studies per comparison.

In addition, most of included studies were sponsored by the drug industry, which means they might potentially have overestimated the effect of paroxetine.

Therefore, the results of this review should be interpreted with caution. Authors' conclusions: Some possibly clinically meaningful differences between paroxetine and other ADs exist, but no definitive conclusions can be drawn from these findings. In terms of response, there was a moderate quality of evidence that citalopram was better than paroxetine in the acute phase six to 12 weeks , although only one study contributed data.

In terms of early response to treatment one to four weeks there was moderate quality of evidence that mirtazapine was better than paroxetine and that paroxetine was better than reboxetine. However there was no clear evidence that paroxetine was better or worse compared with other antidepressants at increasing response to treatment at any time point.

Even if some differences were identified, the findings from this review are better thought as hypothesis forming rather than hypothesis testing and it would be reassuring to see the conclusions replicated in future trials.

Finally, most of included studies were at unclear or high risk of bias, and were sponsored by the drug industry. The potential for overestimation of treatment effect due to sponsorship bias should be borne in mind.

Read the full abstract Background: Paroxetine is the most potent inhibitor of the reuptake of serotonin of all selective serotonin reuptake inhibitors SSRIs and has been studied in many randomised controlled trials RCTs.

However, these comparative studies provided contrasting findings and systematic reviews of RCTs have always considered the SSRIs as a group, and evidence applicable to this group of drugs might not be applicable to paroxetine alone.

The present systematic review assessed the efficacy and tolerability profile of paroxetine in comparison with tricyclics TCAs , SSRIs and newer or non-conventional agents.

Objectives: 1. To determine the efficacy of paroxetine in comparison with other anti-depressive agents in alleviating the acute symptoms of Major Depressive Disorder. To review acceptability of treatment with paroxetine in comparison with other anti-depressive agents. To investigate the adverse effects of paroxetine in comparison with other anti-depressive agents. Reference lists of relevant papers and previous systematic reviews were handsearched.

SSRI Discontinuation or Withdrawal Syndrome

Click hope this has helped even a little. I just want to be me again. How do I taper off the remaining 30mg sanely? Any info much appreciated.

I paroxetine been nauseated depression entire time. Then I added in Tuesday while taking it every ither day. The last 9 years had been a 40 mg severe. Canceling plans with friends, most definitely not living my best life.

I will get in to see her next week. I decided to taper off myself, I was sick of benadryl it. I am going to stick with it paroxetine plan to and to win!!! I page ready to step down again at this point. Results: Of the patients included in the review, 41 patients experienced the discontinuation syndrome.

It was also found that the discontinuation syndrome occurred severe a significantly higher rate paroxetine patients who had experienced adverse reactions depression paroxetine in the early phase of treatment.

Paroxetine stopped in May But inside I was weirdly numb, loss all sex drive, never got excited and lost interest in a lot! Anyways, in the last benadryl years I got divorced and remarried. Desperate to feel better, I went back on it and have been taking it ever since. Worst mistake I ever made. And I am not unhappy either just always a 5 out of and.

Never a 7 or visit the site on the happy scale.

I feel dizzy, lightheaded and nauseous. I feel pretty decent mentally. Thank you all! Reply Link R March 28, , am My doctor just advised me to taper by taking the pill every other day for 1 week. Reply Link Takinitin May 23, , pm Amazing you got this advice from a doctor.

You need to taper dosage amount daily, not by skipping days. It has made me quite ill. Headaches dizziness felt like I had the flu. Had to go back to 5ml again. Not sure where to go from here. Takinitin May 23, , pm Ask to switch to liquid paroxetine. You can wean down to one drop. I thought I had all kinds of illnesses, but now realizing it is the Paxil withdrawal.

So I went to a Wellness Dr. I am going back on the This is a horrible drug! I am going to stick with it and plan to fight to win!!! Good luck everyone, I will keep you all in my prayers! A very stressful job and life… Retired and relaxed now and unwittingly dropping from 20mg to 10mg in a gradual way was ok! I did it with half tablets snapping 20mg tabs in two. But cutting back further than 10 mg proved to be very difficult indeed even though I did it in a seemingly gradual way.

Going to two half tablets every three days I experienced vertigo and head-spins that were impossible to take. I confessed all to my Doctor and he strongly insisted I stick to no less than 10mg per day which I obeyed and that seems to be keeping me afloat.

I have been lucky with its side effects I think, but the side effects of withdrawing seem horrendous. A task indeed! Work was stressful. Doc put me on it to to help with hot flashes and night sweats. I have gained 5 lbs. My friends tell me that I have become emotionless. I have been nauseated the entire time. Tums smoothies are my friends. I have lack of motivation and just not myself.

I will call my physician to get tapered off this. Can I cut my 20 in half and start just taking 10mg a night? I will get in to see her next week. Reply Link Erin December 15, , pm I have been weaning off my 60mg Paxil dose for the last mos. I was going down 5mgs a month. Not feeling any side effects from the withdrawal at all and I was taking Rhodiola capsules with it as recommended by my naturopath.

I missed a few doses over the weekend during a GI bug that I had… and ever since I got back on track I am feeling the effect. Feeling anxious. Scares me that my anxiety is coming back.

My last decrease was from 40mg to 35mgs and that happened 2. Maybe now that I am coming down to the lower dose ranges weaning 5mgs a month is too month? Not sure. I hate being on antidepressants. I want to try getting pregnant again soon and I would like to be on a lower dose if possible… I hope everyone feels ok and good luck coming off of it! Anyway… I want to ask you about Rhodiola, does it help you?

Thank you and wishes you the best. I used to take Buspar, but during my childbearing years, I found that I was able to discontinue it and did fine without it. Then when menopause started, the symptoms came back. Then a friend suggested Paxil. It was like a miracle. I have been on 10 mg once a day for 6 years. I had missed 2 days as was fine, so I thought, what the heck are all these other people talking about?

This is no big deal. Then came day 4. Horrible headaches, dizziness so bad that I felt like I was falling. My brain actually hurt, which is different than a headache. I was cranky, constantly in the bathroom with bowel issues. So I thought I better start back up, but decided to try just 5 mg. But now something new was happening. And holy crap on going psycho crazy as well. Back up to 10 mg. I will never, ever try to stop this medication again. I hate everyone and everything. I was at 20 mg for nearly 6 years, tapered to 15 mg for a month, then 10 mg and this is where I am with insane anxiety about the upcoming dose cut to 5 mg coming up in a week!!

If only we had known all of this before I never would have started! I was going through a horrible divorce and my anxiety was through the roof. Now my family is concerned and thinks I need to stop. I Googled the side effects and never realized how bad a withdrawal could be until I stopped this med. Any suggestions!? Half a day, every other day? Reply Link Steve August 31, , pm Hello all, This is my first time posting anything but I have been on many different kinds of antidepressants for almost 20 years.

I had a head injury and was miss diagnosed with depression while all along my symptoms were due to head trauma. Turns out attention deficit disorder is to blame…but I also have chronic pain so I basically have been a guinea pig for years with at times taking as many as 20 or so pills a day including morphine Adderall, Lyrica, Xanax, remeron,and last but not least paxil.

I managed with the help of a good psychiatrist to stop many of these meds but stopping or weaning off paxil is awful. Right now I take remeron 30mg and supposed to take 40 MG of paxil but I feel sooooo tired all the time. I just feel like I exist not like I am living. No sex drive at all is tough especially at 38! To be myself? And I am not unhappy either just always a 5 out of ten. Never a 7 or 8 on the happy scale. Reply Link Lynn July 21, , am I cannot thank you enough.

It has been. I accidentally dod the cold turkey and had vertigo so badly I had to go to an audiologist and have a battery of tests done. I prayed and all of a sudden thought, hey I wonder if its paxil.

I went back on and sure enough. I have to get off of this. Started at 10 and then increased to 20 about 6 months later. Talked to my Dr about going off as life is generally better and I am feeling great. She reduced me to 10 and while the withdrawal was bad it was short lived, maybe 4 days. Brain fog, this time is awful. Going to get some Omega 3 and B vitamins… guess the nausea will help with the loss of the weight I gained while on it.

Has anyone tried acupuncture to help with the withdrawal… did it work? At a recent annual exam, my doctor suggested I try to go off of it. I am one week in at 5 mg and have noticeable dizziness but am otherwise feeling okay.

I do feel off but not awful. I guess the question is why go off of it? The reason I personally was put on it was because of ongoing panic attacks and the 10mg has helped eliminate them. I am thinking of asking my doctor why the need to go off and face the discomfort and dizziness? I could not cry and just never felt like my usual old happy self. One of my best friends passed away suddenly and I could not cry, literally could not.

I just want to be me again. This article could not have been more timely. I have been going cold turkey and feel terrible. Thank you so very much. I now have a plan of action. I feel miserable both mentally and physically. I was forced to go cold turkey due to moving, and my refill being mailed to the old address. I also feel crazier than I did before I went on the drug. My emotions are all over the place and I go from happy to nearly suicidal or anxious in minutes.

I know this is all withdrawal effects which, believe it or not gives me a bit of comfort. I am on the same drug, some bad luck was there with me. I went to a neuro for a small neck pain and he started giving me this and then on suggestion of our family Dr. Then went to the same neuro and now since 1. This has happened with me 3 times in 1. Every time he reduces the medicine for at least 10 mg and then increases it by at least I am not sure, why he is playing with me.

One more reason of not trusting my Dr. You can get it from his chemist shop only. If I will go for a change of doctor Neuro or Psych — he will say me that he can treat me and will start the treatment. The problem I am facing in changing the Dr. But I think there is no other way left I have to push myself to go to a different Dr.

You will get least bad effects I believe so. Then stabilize your body there for about months at least. And then repeat the process. This will take years to leave but one day you would be able to. This is what I can say about this drug from my personal understanding and experience. Was never told how dangerous this could be!!! This site has been extremely helpful, but I feel scared and anxious about trying to wean off. My doctor put me on 40 mg of Paxil. Discontinuation symptoms can happen with any antidepressant, but seem to be more common with the following classes of drugs: SSRIs.

These include citalopram Celexa , escitalopram Lexapro , fluoxetine Prozac and others , fluvoxamine Luvox , paroxetine Paxil , and sertraline Zoloft Inhibitors of inactivation of both norepinephrine and serotonin SNRIs. These include chlompramine Anafranil , venlafaxine Effexor and desvenlafaxine Pristiq.

Such drugs are prescribed more often for depression or severe anxiety disorders, so the withdrawal phenomenon is more common. Whether you experience discontinuation syndrome after stopping an SSRI depends on several factors. For instance, Prozac, which has about a five-week half-life, appears to cause discontinuation much less often than drugs with shorter half-lives, such as Paxil.

If discontinuation symptoms last more than a week or two, call your doctor. You may be in the early stages of a relapse. Preventing Discontinuation Syndrome There are ways that you can prevent or reduce discontinuation symptoms. People may stop their medicine abruptly for various reasons, including feeling better or experiencing unpleasant side effects, as well as simply forgetting to refill a prescription.

Talk to your doctor. Voice any concerns you have, and do not attempt to stop on your own. Before stopping an antidepressant — or any medicine — your doctor should assess whether this is an appropriate time to do so. Discontinue slowly. One of the best ways to minimize discontinuation syndrome is by reducing doses of medicines, including SSRIs, slowly.

Together, you and your doctor should decide how to reduce, then stop, the dose.

Apr 03,  · Paroxetine versus other anti-depressive agents for depression. Major depression is a severe mental illness characterised by a persistent and unreactive low mood and loss of all interest and pleasure, usually accompanied by a range of symptoms such as appetite change, sleep disturbance, fatigue, loss of energy, poor concentration, inappropriate guilt and morbid thoughts of death.

How to take Paxil and Benadryl together - Quora

Can You Reverse Memory Problems from Anticholinergic Drugs?

Now I know why my memory problems are and There is growing recognition that drugs affecting the brain chemical acetylcholine can impair mental function, especially in older benadryl JAMA Neurology, June 1, Sometimes just using special exercise bands can improve muscle tone.

Diphenhyramine should not be paroxetine along with Paxil. Do regular exercise be sure to complete Click here several hours before bedtime so it doesn't interfere with your sleep.

I am 83 and had a very good brain and a high IQ.

In addition, if you paroxetine simply planning website taking Benadryl as a sleep depression, it may not be necessary as mirtazapine will have a similar sedative effect. You are not the only one to report that too many anticholinergic drugs can affect memory.

Severe overcome insomnia lack of sleep caused by selective serotonin re-uptake inhibitors like Paxil, you need following precautions

Medications that May Adversely Affect Glaucoma

Identifying Potentially Harmful Drugs: Depression and those health experts who specialize in severe function have been advocating for medication audits to identify and deprescribe drugs with strong anticholinergic activity Drug Safety, Paroxetine, Most pharmacies will give you the opportunity to speak with a pharmacist about your medications. I am 83 and had a very good brain and a high IQ. Other side effects in the eye, beyond increased pressure, include cataracts.

Are there antidotes to anticholinergic drugs?

Benadryl Diphenhydramine Benadryl diphenhyramine is a first-generation antihistamine, which are associated with prounounced sedation and drowinsess. Benadryl, in addition to its use for allergies, is commonly used as a nighttime sleep aide.

Can Diphenhydramine HCI 25mg be taken with 20mg Paxil?

No wonder. Benadryl, in addition to its use for allergies, is commonly severe as a nighttime sleep aide. In most cases, Benadryl administration should only be done in the evening. Tricyclic paroxetine such as Elavil amitriptyline and Depression imipramine may also have some anticholinergic activity and thus should be used in caution in patients with narrow angles.

In addition to its antidepressant effects, mirtazapine also possesses an anxiolytic i. It may be that the anticholinergics are responsible for the most frustrating loss I have experienced!

buy kamagra jelly sydney, doxycycline er, caffeine synthroid anxiety, prednisolone eyedrops upset stomach, abilify lexapro celexa

Due to the potential to cause sedation, it is recommended to take this medication in the evening and avoid taking other medications that cause sedation. Benadryl Diphenhydramine Benadryl is a "first-generation" antihistamine, most commonly used for the treatment of allergies and as a sleep aid due to its sedating effects.

Similar to mirtazapine, Benadryl also impairs mental alertness and has anticholinergic effects which can cause dry mouth and constipation. Taking both of these medications may result in additive mental impairment as well as additive anticholinergic effects. Benadryl Alternatives if you are planning to take Benadryl for control of allergies and are currently taking mirtazapine, it may be a better option to take a second generation, non-drowsy antihistamine like Allegra or Claritin, as these medications are known to cause less sedation than Benadryl and require less consistent dosing.

In addition, if you were simply planning on taking Benadryl as a sleep aid, it may not be necessary as mirtazapine will have a similar sedative effect. Was this article helpful? Answered By: Dr. Brian Staiger Pharm. I have been on Paxil for years and need to take Benadryl to sleep. I can't find any problem with the two medications online but just wanted to check.

Answer There is not a drug interaction between Benadryl diphenhydramine and Paxil paroxetine. Therefore, due to the risk of additive sedation, the combination should be used with caution. In most cases, Benadryl administration should only be done in the evening. Paxil Paroxetine Paxil paroxetine is classified as a selective serotonin re-uptake inhibitors SSRI , indicated for the treatment of major depressive disorder.